FLT3-ITD and NPM1 Double Mutation Acute Myeloid Leukemia Case Presenting with Diffuse Skin Granulocytic Sarcoma

Objective: Acute myeloid leukemia (AML) is characterized by leukemic blasts that are not limited to the bone marrow or peripheral blood, may be presented with granulocytic sarcoma, and cells outside of blood called extramedullary involvement (EMI). Skin, bone, lymph nodes most prevalent locations illness. Granulocytic sarcoma (GS) should considered in differential diagnosis nodules, pustules, plaque-like lesions, especially patients suspected hematological disease. No EMI-specific treatment regimens have been established; who suitable for intensive therapy typically treated anthracycline cytarabine-containing regimens. The common genetic aberration adult AML somatic mutations exon 12 NPM gene (NPM1), which affect up 60% individuals normal karyotype around 35% all cases. Patients NPM1 twice as likely also a FMS-like tyrosine kinase internal transmembrane duplications (FLT3-ITD) mutation without mutations. frequently harbors FLT3 result alterations domain's activating loop (FLT3-TKD). Short remissions unfavorable outcomes linked high proportion FLT3-ITD molecules on their surface. Case: Here this study, we report patient diagnosed double (FAB classification M0, M1), admitted diffuse sarcoma.